Bioinformatics V germline genes

Antibodies are specialized proteins of the immune system that recognize and neutralize specific antigens. Each antibody consists of two heavy and two light chains, with variable regions (Fv) at their tips responsible for antigen recognition. This project will be solely focused on the Fv region. The variable regions include complementarity-determining regions (CDR loops), which are highly diverse and form the primary contact points with antigens. The genetic diversity of these regions arises from the rearrangement of variable (V), diversity (D), and joining (J) germline gene segments during B cell development. This combinatorial assembly, coupled with junctional diversity and somatic hypermutation, generates an immense repertoire of antibodies, enabling the immune system to target a wide array of pathogens. This project is focused only on the V germline genes.